people health life 25

"The increased interdependency of countries, economies, and cultures resulting from tremendous growth in international travel and trade over the last several decades has brought improved access to goods and services, but also a variety of health threats," said Jendayi Frazer, co-chair of the committee that conducted the study and wrote the report and adjunct senior fellow for Africa studies at the Council on Foreign Relations. "The United States must preserve and extend its legacy as a global leader, partner, and innovator in global health through forward-looking policies, country and international partnerships, and, most importantly, continued investment. Doing so will not only lead to improved health and security for all U.S. citizens but also ensure the sustainable thriving of the global population." "By investing in global health over the next 20 years, there is a chance to save the lives of millions of children and adults," said committee co-chair...

Now, a team of scientists at UC Santa Cruz and the National Institutes of Health has obtained the first glimpse of the molecular mechanism by which recognition of an antigen (such as a viral protein) by the T cell receptor triggers the first steps leading to an immune response. The new findings, published May 16 in  Nature Communications , implicate changes in the molecular structure of the T cell receptor that propagate from the antigen recognition site on the outside of the cell to a signaling site inside the cell. The activation signal then triggers a complex "signaling cascade" within the T cell, leading to a range of possible responses by the cell. "This provides the first hint of the mechanism that triggers that signaling cascade," said Nikolaos Sgourakis, assistant professor of chemistry and biochemistry  at UC Santa Cruz and co-senior author of the paper. "We don't yet have a full reconstruction of the signaling system, but for the first time ...